6H-Dibenzo[b,d]pyran-1-ol,6a,7,10,10a-tetrahydro-6,6,9-trime
- 中文别名：DEA限制
- 中文释义：(-)-Δ8-四氢大麻酚;DEA限制
- 英文别名：?8-Tetrahydro Cannabinol;
δ-8-THC
- cas No.：5957-75-5
- 分子式：C21H30O2
- 分子量：314.51
- 精确分子量：314.22500
- PSA：29.46000
- InChI：The Key: HCAWPGARWVBULJ-ZYMOGRSISA-N
- 分子结构式：
物化性质
- 密度：
- 1.015 g/cm3
- 沸点：
- 383.5ºC at 760 mmHg
- 闪点：
- 144.5ºC
- 折射率：
- 1.528
安全信息
- 密度：
- 1.015 g/cm3
- 沸点：
- 383.5ºC at 760 mmHg
- 闪点：
- 144.5ºC
- 折射率：
- 1.528
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HP8400000
- CHEMICAL NAME :
- 6H-Dibenzo(b,d)pyran-1-ol, 6a,7,10,10a-tetrahydro-3-pentyl-6,6,9-trimethyl-, trans(-)-
- CAS REGISTRY NUMBER :
- 5957-75-5
- BEILSTEIN REFERENCE NO. :
- 0023921
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C21-H30-O2
- MOLECULAR WEIGHT :
- 314.51
- WISWESSER LINE NOTATION :
- T B666 HO MU&TTJ CQ E5 I1 I1 M1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 860 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 560 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - analgesia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 97 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - analgesia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- >3150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 59500 mg/kg/17W-I
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - aggression Related to Chronic Data - death
- TYPE OF TEST :
- DNA inhibition
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- REFERENCE :
- RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 17,703,1977
