- 中文别名：氟米松
- 中文释义：氟米松;6Α-氟地塞米松;氟甲松
- 英文别名：flumethasone;
flumetasone;
Anaprime;
6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione;
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;
Flumethason;
Fluvet;
Flumethasone;
6α-Fluorodexamethasone;
Cortexilar;
Flucorticin;
6α,9α-Difluoro-16α-methylprednisolone;
Aniprime;
Methagon - cas No.：2135-17-3
- 分子式：
C22H28F2O5
- 分子量：410.46
- 精确分子量：410.19000
- PSA：94.83000
- InChI：InChI=1/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13?,14?,16+,17+,19+,20+,21+,22+/m1/s1
- 分子结构式：
物化性质
- 密度：
- 1.36 g/cm3
- 熔点：
- 237-240ºC
- 沸点：
- 569.8ºC at 760 mmHg
- 闪点：
- 298.4ºC
- 折射率：
- 1.579
- 蒸汽压：
- 2.33E-15mmHg at 25°C
安全信息
- 密度：
- 1.36 g/cm3
- 熔点：
- 237-240ºC
- 沸点：
- 569.8ºC at 760 mmHg
- 闪点：
- 298.4ºC
- 折射率：
- 1.579
- 蒸汽压：
- 2.33E-15mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU3832000
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl-
- CAS REGISTRY NUMBER :
- 2135-17-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C22-H28-F2-O5
- MOLECULAR WEIGHT :
- 410.50
- WISWESSER LINE NOTATION :
- L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1 FQ G1 LF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 20 ug/kg
- SEX/DURATION :
- female 38 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 28,407,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 30 ug/kg
- SEX/DURATION :
- female 31 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion
- REFERENCE :
- JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 160,867,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 20 ug/kg
- SEX/DURATION :
- female 40 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition
- REFERENCE :
- THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 20,267,1983
分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:3
3.氢键受体数量:7
4.可旋转化学键数量:2
5.互变异构体数量:3
6.拓扑分子极性表面积:94.8
7.重原子数量:29
8.表面电荷:0
9.复杂度:839
10.同位素原子数量:0
11.确定原子立构中心数量:9
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1